Biochemical markers of brain tumours

The paper presents the results of neurospecific proteins S-100 and glial fibrillary acidic protein (GFAP) determination in blood serum samples of 145 neuro-oncology patients and 69 healthy people. The significant elevation of S-100 and GFAP was revealed in glioblastoma (G IV) patients compare to the...

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Bibliographic Details
Published inKlinicheskaia laboratornaia diagnostika no. 10; p. 71
Main Authors Lyubimova, N V, Toms, M G, Fu, R G, Bondarenko, Yu V
Format Journal Article
LanguageEnglish
Published Russia (Federation) 01.10.2013
Subjects
Adaptor Proteins, Signal Transducing - blood
Adolescent
Adult
Aged
Astrocytoma - blood
Astrocytoma - diagnosis
Biomarkers, Tumor - blood
Brain Neoplasms - blood
Brain Neoplasms - diagnosis
Brain Neoplasms - secondary
Case-Control Studies
Female
Glioblastoma - blood
Glioblastoma - diagnosis
Humans
Male
Meningioma - blood
Meningioma - diagnosis
Middle Aged
S100 Proteins - blood
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Summary:The paper presents the results of neurospecific proteins S-100 and glial fibrillary acidic protein (GFAP) determination in blood serum samples of 145 neuro-oncology patients and 69 healthy people. The significant elevation of S-100 and GFAP was revealed in glioblastoma (G IV) patients compare to the patients with anaplastic astrocytoma (G III), benign meningioma (GI), celebral metastasis and healthy controls. The concentration of S-100 in blood serum of patients with anaplastic astrocytoma, benign meningioma, and celebral metastasis did not significantly differ among themselves, and in relation to the control group there was a significantly increase only in patients with cerebral metastasis. GFAP was characterized by high frequency of its detection in patients with glioblastoma (83%) compare to other groups of patients and healthy donors, in which it was practically undetectable. These data suggest the possibility of using GFAP as a marker of glioblastoma and S-100- as an additional biochemical criteria of cerebral lesions in oncology patients.
ISSN:0869-2084