Synthesis of beta-cyclodextrin polymer beads and its behavior of drug release

To prepare beta-cyclodextrin polymer (beta-CDP) beads using as a drug carrier and study the release behaviors of Berberine Hydrochlorrde (BH) in beta-CDP beads. beta-CDP beads were synthesized by inverse emulsion polymerization. The inclusion complex between beta-CD and BH were investigated by phase...

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Bibliographic Details
Published inZhong yao cai Vol. 30; no. 3; p. 329
Main Authors Wu, Wen-juan, Zheng, Dun-sheng, Cai, Shi-tian, Huang, Yuan-keng
Format Journal Article
LanguageChinese
Published China 01.03.2007
Subjects
Cellulose - chemical synthesis
Cellulose - chemistry
Cyclodextrins - chemical synthesis
Cyclodextrins - chemistry
Delayed-Action Preparations
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
Drug Liberation
Hydrogen-Ion Concentration
Solubility
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Summary:To prepare beta-cyclodextrin polymer (beta-CDP) beads using as a drug carrier and study the release behaviors of Berberine Hydrochlorrde (BH) in beta-CDP beads. beta-CDP beads were synthesized by inverse emulsion polymerization. The inclusion complex between beta-CD and BH were investigated by phase solubility method. And the release of BH in vitro was studied by UV spectra. Inclusion compounds of beta-CD and BH with 1: 1 molar ratio were found under the condition of pH 1.4 and pH 7.4, with corresponding stability constants of 48.85 L/mol and 122.11 L/mol, respectively. Finally, the controlled release behavior of BH in polymer beads were studied and the release rate of BH kept almost constant after 24 h. Release rate of BH was higher at pH 1.4 than that at pH 7.4. beta-CDP beads may be an ideal controlled drug release carrier.
ISSN:1001-4454