Analysis of clinical feature and treatment outcome in 42 patients with lymphoblastic lymphoma

• Published in: Zhōnghuá xuèyèxué zázhì Vol. 30; no. 7; p. 446
• Main Authors: Lu, Bin, Li, Qian, Zou, De-Hui, Zhao, Yao-Zhong, Qi, Jun-Yuan, Xu, Yan, Qui, Lu-Gui
• Format: Journal Article
• Language: Chinese
• Published: China 01.07.2009
• Subjects: Adolescent; Adult; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy; Retrospective Studies; Treatment Outcome; Young Adult
• ISSN: 0253-2727

To investigate the clinical features and treatment outcomes of different regimens in Chinese patients with lymphoblastic lymphoma (LBL). Forty-three patients with LBL were retrospectively analysed, of which 30 were T-LBL, and 13 B-LBL. (1) Most patients were young men with a median age of 21, and 63.0% of the T-LBL patients had mediastinal masses. (2) Treatment outcome could be assessed in 37 cases, of which the response rate (RR) was 81.1% and complete remission (CR) rate was 67.6%. The RR and CR rates in patients treated with regimens for ALL (ALL-like group) and those treated with regimens for NHL (NHL-like group) were 94.4%, 68.4% and 83.3%, 52.6%, respectively. (3) The estimated median overall survival (OS) and progression free survival (PFS) of hematopoietic stem cell transplantation (HSCT) group were significant longer than those of ALL-like group (P=0.018, P=0.025) and NHL-like group (P=0.016, P=0.011). The OS at 5 years in NHL-like group, ALL-like group and HSCT group were (14.4+/-9.4)%, (20.2+/-12.7