Analysis of clinical feature and treatment outcome in 42 patients with lymphoblastic lymphoma

To investigate the clinical features and treatment outcomes of different regimens in Chinese patients with lymphoblastic lymphoma (LBL). Forty-three patients with LBL were retrospectively analysed, of which 30 were T-LBL, and 13 B-LBL. (1) Most patients were young men with a median age of 21, and 63...

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Published inZhōnghuá xuèyèxué zázhì Vol. 30; no. 7; p. 446
Main Authors Lu, Bin, Li, Qian, Zou, De-Hui, Zhao, Yao-Zhong, Qi, Jun-Yuan, Xu, Yan, Qui, Lu-Gui
Format Journal Article
LanguageChinese
Published China 01.07.2009
Subjects
Adolescent
Adult
Child
Child, Preschool
Female
Follow-Up Studies
Humans
Male
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Retrospective Studies
Treatment Outcome
Young Adult
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Summary:To investigate the clinical features and treatment outcomes of different regimens in Chinese patients with lymphoblastic lymphoma (LBL). Forty-three patients with LBL were retrospectively analysed, of which 30 were T-LBL, and 13 B-LBL. (1) Most patients were young men with a median age of 21, and 63.0% of the T-LBL patients had mediastinal masses. (2) Treatment outcome could be assessed in 37 cases, of which the response rate (RR) was 81.1% and complete remission (CR) rate was 67.6%. The RR and CR rates in patients treated with regimens for ALL (ALL-like group) and those treated with regimens for NHL (NHL-like group) were 94.4%, 68.4% and 83.3%, 52.6%, respectively. (3) The estimated median overall survival (OS) and progression free survival (PFS) of hematopoietic stem cell transplantation (HSCT) group were significant longer than those of ALL-like group (P=0.018, P=0.025) and NHL-like group (P=0.016, P=0.011). The OS at 5 years in NHL-like group, ALL-like group and HSCT group were (14.4+/-9.4)%, (20.2+/-12.7
ISSN:0253-2727