A case of advanced gastric cancer successfully treated by combination therapy of S-1 and docetaxel

• Published in: Gan to kagaku ryoho Vol. 35; no. 2; p. 287
• Main Authors: Ikarashi, Satoshi, Akiyama, Nobuhiro, Motoyama, Hirotaka, Sasaki, Syunya, Ito, Hiromi, Funakoshi, Kazuhiro, Kato, Toshiyuki, Arai, Futoshi
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.02.2008
• Subjects: Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biomarkers, Tumor - blood; Drug Combinations; Female; Gastroscopy; Humans; Male; Neoplasm Staging; Oxonic Acid - therapeutic use; Stomach Neoplasms - blood; Stomach Neoplasms - drug therapy; Stomach Neoplasms - pathology; Taxoids - therapeutic use; Tegafur - therapeutic use; Tomography, X-Ray Computed
• ISSN: 0385-0684

A 70-year-old man with gastric cancer of Borrmann type 3, liver metastases and peritoneal dissemination was treated by combination therapy of S-1 and docetaxel (DOC). He received DOC intravenously at 40 mg/m(2) on day 1 and S-1 orally at 100 mg/body on day 1 to 14, repeated every 28 days. After 2 courses of treatment, a CT scan revealed improvement of the gastric wall thickness, the eminent decrease of the peritoneal fluid and the reduction of the liver metastasis. After 3 courses of treatment, the primary lesion was remarkably improved on endoscopic examination, and the tumor marker normalized after 4 courses of treatment. Toxicities included leukocytopenia (WHO grade 3), neutropenia ( grade 3), anorexia (grade 2), and nausea (grade 2). Outpatient chemotherapy was possible by reduction of dose (S-1 100--> 80 mg/body, DOC 40--> 32 mg/m2). The response was maintained on CT and endoscopic examination after 21 courses of treatment. A case of an advanced gastric cancer patient successfully treated by combination therapy of S-1 and DOC was reported.