The relationship between the new inflammatory markers and disease severity in patients with acute coronary syndrome

• Published in: Acta cardiologica p. 1
• Main Authors: Seydel, Gonul Seyda, Gunturk, Inayet, Akkaya, Hasan, Gunturk, Ertugrul Emre
• Format: Journal Article
• Language: English
• Published: England 17.09.2024
• Subjects: inflammatory markers; fibrinogen-to-albumin ratio; SYNTAX score; Acute coronary syndrome
• ISSN: 1784-973X
• DOI: 10.1080/00015385.2024.2403933

Inflammation plays a crucial role in the progression of acute coronary syndrome. The aim of this study was to investigate the relationship between the SYNTAX score and new inflammatory markers including albumin-globulin ratio (AGR), C-reactive protein-to-albumin ratio (CAR), fibrinogen-to-albumin ratio (FAR), neutrophil-to-albumin ratio (NAR), and neutrophil percentage-to-albumin ratio (NPAR) in STEMI and NSTEMI patients. The study involved 53 STEMI and 64 NSTEMI patients, and each patient group was evaluated separately. Multivariate linear regression analysis was utilised to identify independent risk factors associated with SYNTAX scores. Out of the 64 NSTEMI patients, 42 had low SYNTAX score (65.6%), and 22 had high SYNTAX score (34.4%). Patients with high SYNTAX scores had significantly higher levels of age, glucose, fibrinogen, monocyte, and FAR, and lower levels of albumin and total protein. We found that FAR and monocyte levels were independent predictors of the high SYNTAX score. The study also determined that the cut-off value for FAR as 9.99, with a sensitivity of 81% and a specificity of 73% for predicting high SYNTAX score in NSTEMI patients. Out of the 53 STEMI patients, 42 had low SYNTAX score (79.2%), and 11 had high SYNTAX score (20.8%). Patients with high SYNTAX scores exhibited significantly higher total cholesterol, LDL, and glucose levels, and lower albumin and total protein levels. The FAR level is significantly linked with the high SYNTAX score and can be a useful marker for predicting the severity of disease in NSTEMI patients.