Associated sedation of propofol and midazolam in small dosage and gastroscopy

• Published in: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University Vol. 26; no. 5; p. 463
• Main Authors: Tang, W L, Liu, S J, Jiang, X W
• Format: Journal Article
• Language: Chinese
• Published: China 28.10.2001
• Subjects: Adult; Female; Gastroscopy; Humans; Hypnotics and Sedatives - administration & dosage; Male; Midazolam - administration & dosage; Middle Aged; Propofol - administration & dosage
• ISSN: 1000-5625

To search for a sedative method that is more suitable for gastroscopy. All of patients were randomly divided into control group and experimental group. The experimental group was treated with propofol and midazolam, the control group was treated with propofol alone. The cumulation dosage of propofol, sedative effect, variation of BP and SaO2 were observed in all patient. The cumulative dosage of propofol in the experimental group was lower than that in the control group [(73.21 +/- 18.67) mg and (117.23 +/- 21.57) mg respectively]; the oblivious degree in the experimental group was higher than that in the control group (95.65% and 80.00%); the onset time and the descendant range of BP and SaO2 were also lower in the experimental than those in the control group. There was not remarkable difference in sedative effect and veriviscont time between the control group and the experimental group. In such a rapid operation of gastroscopy, the dosage of propofol in the experimental group is obviously less than that in