Muscarinic M3 receptors mediate contraction of human central and peripheral airway smooth muscle

The muscarinic receptor subtype involved in human airway smooth muscle contraction was characterised for the first time, using subtype-selective muscarinic antagonists. It was demonstrated that methacholine-induced contraction of central (trachea) and peripheral (small bronchi) airway smooth muscle...

Full description

Saved in:
Bibliographic Details
Published inPulmonary pharmacology (Edinburgh) Vol. 3; no. 1; p. 47
Main Authors Roffel, A F, Elzinga, C R, Zaagsma, J
Format Journal Article
LanguageEnglish
Published England 1990
Subjects
Bronchi - physiology
Humans
In Vitro Techniques
Ipratropium - pharmacology
Muscle Contraction - physiology
Muscle, Smooth - physiology
Parasympatholytics - pharmacology
Piperidines - pharmacology
Pirenzepine - analogs & derivatives
Pirenzepine - pharmacology
Receptors, Muscarinic - physiology
Trachea - physiology
Online AccessGet full text

Cover

More Information
Summary:The muscarinic receptor subtype involved in human airway smooth muscle contraction was characterised for the first time, using subtype-selective muscarinic antagonists. It was demonstrated that methacholine-induced contraction of central (trachea) and peripheral (small bronchi) airway smooth muscle preparations was antagonised by pirenzepine, AF-DX 116, 4-DAMP methobromide, hexahydrosiladifenidol, and methoctramine with pA2-values characteristic of M3 (smooth muscle/glandular) muscarinic receptors. Since these pA2-values demonstrate significant correlations with those found in bovine and guinea-pig tracheal smooth muscle contraction, it is concluded that these animal tissues provide a good model for the study of M3 subtype-selective muscarinic antagonists to be used as bronchodilators.
ISSN:0952-0600
DOI:10.1016/0952-0600(90)90009-8