Circadian patterns of growth hormone, prolactin and corticotrophin secretion in hypothalamic and extra-hypothalamic lesions localized by stereotactic neuro-radiology in humans

The integrity of mediobasal hypothalamus for the maintenance of normal circadian rhythms has been clearly established in the animal. Using precise stereotactic neuroradiologic localisations of various brain tumors, the authors demonstrate that in human, cortical lesions induce no significant modific...

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Bibliographic Details
Published inActa psychiatrica Belgica Vol. 80; no. 4; p. 376
Main Authors Schaub, C, Betti, O, Bluet-Pajot, M T, Vedrenne, C, Lornet-Videau, C, Szikla, G
Format Journal Article
LanguageEnglish
Published Belgium 01.07.1980
Subjects
Adrenocorticotropic Hormone - secretion
Brain Neoplasms - physiopathology
Circadian Rhythm
Growth Hormone - secretion
Humans
Hypothalamus - physiology
Prolactin - secretion
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Summary:The integrity of mediobasal hypothalamus for the maintenance of normal circadian rhythms has been clearly established in the animal. Using precise stereotactic neuroradiologic localisations of various brain tumors, the authors demonstrate that in human, cortical lesions induce no significant modifications of the circadian variation of GH, prolactin or ACTH. In contrast subcortical lesions displacing the 3rd ventricle result in an inhibiton of the nocturnal rise in GH and prolactin, whereas the circadian rhythm of ACTH remains normal.
ISSN:0300-8967