Diagnostic value of blood thiamine metabolites in Alzheimer's disease examined by 11C-PiB PET scanning

AIMWe evaluated the diagnostic value of blood thiamine metabolites for Alzheimer's disease (AD) by using positron emission tomography with 11C-Pittsburgh compound B (11C-PiB PET) scanning. METHODSThirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabolite...

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Published inFuture science OA Vol. 3; no. 2; p. FSO172
Main Authors Chen, Zhichun, Pan, Xiaoli, Fei, Guoqiang, Pan, Shumei, Bao, Weiqi, Ren, Shuhua, Guan, Yihui, Zhong, Chunjiu
Format Journal Article
LanguageEnglish
Published London, UK Future Science Ltd 01.06.2017
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Preliminary Communication
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Summary:AIMWe evaluated the diagnostic value of blood thiamine metabolites for Alzheimer's disease (AD) by using positron emission tomography with 11C-Pittsburgh compound B (11C-PiB PET) scanning. METHODSThirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabolites were measured by high-performance liquid chromatography. All the patients received 11C-PiB PET scanning for the measurement of cerebral amyloid deposition. RESULTSThiamine diphosphate (TDP) had 66.7% sensitivity and 80.0% specificity for AD diagnosis, while the γ-value representing the best combination of thiamine metabolites and age had 24.2% sensitivity and 100.0% specificity according to the cut-off value of our previous study. CONCLUSIONBlood TDP but not γ-value exhibited results significant for AD diagnosis.
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Authors contributed equally
ISSN:2056-5623
2056-5623
DOI:10.4155/fsoa-2016-0087