Studies on variation of danshensu content in accelerated stability tests

To study the variation Laws of content of danshensu accelerated in control and in danshen injection in order to provide reference for stability investigation of danshensu. The tests was carried out by classic isothermal method and the content of danshensu was determined by HPLC. The contents of dans...

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Bibliographic Details
Published inZhongguo zhongyao zazhi Vol. 28; no. 3; p. 220
Main Authors Mao, Sheng-jun, Hou, Shi-xiang, Tang, Chang-jiong, Huang, Xiao-dong
Format Journal Article
LanguageChinese
English
Published China 01.03.2003
Subjects
Chromatography, High Pressure Liquid
Drug Stability
Hydrolysis
Hydroxybenzoates - chemistry
Injections
Lactates - administration & dosage
Lactates - analysis
Lactates - chemistry
Temperature
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Summary:To study the variation Laws of content of danshensu accelerated in control and in danshen injection in order to provide reference for stability investigation of danshensu. The tests was carried out by classic isothermal method and the content of danshensu was determined by HPLC. The contents of danshensu in accelerated tests increase in control and decrease in danshen injection respectively. The component of phenic acidity would be hydrolyzed to become danshensu in the accelerated tests. Much attention should be paid to the unusual increase when studies of danshen preparations are carried out.
ISSN:1001-5302