KatG Ser3 15Thr mutation as the main reason of isoniazid resistance in Mycobacterium tuberculosis isolated in the Novosibirsk and Kemerovo Regions

KatG Ser3 15Thr mutation is one of the main reasons of resistance to isoniazid in Mycobacterium tuberculosis isolates. The frequency rate of the above mutation among isoniazid-resistant isolates made 94% in Novosibirsk Region and 93% in Kemerovo Region. The use of PCR-restriction fragment length pol...

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Published inMolekulârnaâ genetika, mikrobiologiâ i virusologiâ no. 3; p. 8
Main Authors Voronina, E N, Vikhrova, M A, Khrapov, E A, Kinsht, V N, Norkina, O V, Gorbunova, E V, Shabaldin, A V, Glushkov, A N, Krasnov, V A, Filipenko, M L
Format Journal Article
LanguageRussian
Published Russia (Federation) 2004
Subjects
Adolescent
Adult
Aged
Amino Acid Substitution
Antitubercular Agents - pharmacology
Bacterial Proteins - genetics
Catalase - genetics
Drug Resistance, Bacterial - genetics
Humans
Isoniazid - pharmacology
Middle Aged
Mutation
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Serine
Siberia
Threonine
Siberia
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Summary:KatG Ser3 15Thr mutation is one of the main reasons of resistance to isoniazid in Mycobacterium tuberculosis isolates. The frequency rate of the above mutation among isoniazid-resistant isolates made 94% in Novosibirsk Region and 93% in Kemerovo Region. The use of PCR-restriction fragment length polymorphism (PCR-RFLP) can be regarded as an adequate method for rapid screening of isoniazid resistance in Mycobacterium tuberculosis isolated in the West-Siberian Region.
ISSN:0208-0613