Similar cellular proliferation activities in nasal polyps and adjacent inferior turbinate

• Published in: American journal of otolaryngology Vol. 33; no. 1; pp. 14 - 19
• Main Authors: WU, Chia-Chen, LEE, Ta-Jen, CHANG, Po-Hung, TSAI, Chi-Neu, LEE, Yun-Shien, FU, Chia-Hsiang, HUANG, Chi-Che
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier 2012
• Subjects: Adult; Aged; Biological and medical sciences; Biomarkers - metabolism; Case-Control Studies; Cell Proliferation; Eosinophil Major Basic Protein - metabolism; Eosinophils - metabolism; Female; Humans; Immunohistochemistry; Male; Medical sciences; Middle Aged; Nasal Mucosa - metabolism; Nasal Polyps - metabolism; Otorhinolaryngology. Stomatology; Proliferating Cell Nuclear Antigen - metabolism; Proto-Oncogene Proteins c-fos - metabolism; Proto-Oncogene Proteins c-jun - metabolism; Rhinitis - metabolism; Sinusitis - metabolism; Statistics, Nonparametric; Tumors; Turbinates - metabolism; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; ENT disease; Nose disease; ENT; Nasal polyp; Cell; Turbinate bone
• ISSN: 0196-0709; 1532-818X; 1532-818X
• DOI: 10.1016/j.amjoto.2010.12.001

Nasal polyps (NP) are regulated by proinflammatory transcription factors such as activator protein-1 (AP-1), which comprises members of the proto-oncogene Jun and Fos protein families. The binding of AP-1 proteins to the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element can activate target genes and regulate many critical cellular processes. The proliferating cell nuclear antigen (PCNA) gene contains AP-1 sites, and its expression is regulated by AP-1 activity. In this study, NP and inferior turbinate (IT) were evaluated, compared with normal mucosa, to see if diffuse inflammation and active cellular proliferation exist. A diseased group of 20 subjects and control group of 20 subjects were enrolled in this study. NP and IT were evaluated with expression of phospho-c-Jun, c-Fos, PCNA, major basic protein by immunohistochemistry, and eosinophil numbers by cell counts. The expression of phospho-c-Jun, c-Fos, PCNA, major basic protein, and eosinophil numbers showed no significant difference in IT and NP of the same patients, but all were significantly higher in IT and NP compared with normal mucosa (P < .05). Our result demonstrated strong evidence that diffuse mucosal inflammation and active cellular proliferation do exist in rhinosinusitis with nasal polyposis. As the degree of the disease severity increases, the difference of eosinophilic infiltration and cellular proliferation activity between NP and its adjacent mucosa decreases. An integrated anti-inflammatory treatment may be more important than surgical intervention.