Spectrum of cytokines produced by blood leukocytes in infection of herpes simplex virus, type 1

Three types of reaction of human blood leucocytes to herpes simplex virus 1 (HSV-1) were detected. The first reaction type, i.e. production of IFN-alpha, IFN-gamma, IL-1beta, IL-6 and TNFalpha but not of IL-2 or IL-4, denotes the primary body reaction to an infectious agent. The second reaction type...

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Bibliographic Details
Published inVoprosy virusologiĭ Vol. 49; no. 4; p. 39
Main Authors Shcheglovitova, O N, Maksianina, E V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2004
Subjects
Animals
Cells, Cultured
Cercopithecus aethiops
Coculture Techniques
Cytokines - analysis
Cytokines - biosynthesis
Herpesvirus 1, Human - physiology
Humans
Interferons - analysis
Interferons - biosynthesis
Interleukins - analysis
Interleukins - biosynthesis
Leukocytes - immunology
Leukocytes - virology
Lymphocyte Activation
Time Factors
Vero Cells
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Summary:Three types of reaction of human blood leucocytes to herpes simplex virus 1 (HSV-1) were detected. The first reaction type, i.e. production of IFN-alpha, IFN-gamma, IL-1beta, IL-6 and TNFalpha but not of IL-2 or IL-4, denotes the primary body reaction to an infectious agent. The second reaction type is related with infection of activated HSV-1 leucocytes and is accompanied by an inhibited production of IFN-gamma, IL-6 and IL-8, which is targeted at suppressing the antivirus cell mechanisms. The third reaction type is associated with production of IFN-alpha, IFN-gamma, IL-beta, IL-6 and TNFalpha by blood leucocytes affected by HSV-1-infected leucocytes.
ISSN:0507-4088