Effect of riodoxol on herpes simplex virus morphogenesis in experimental eye infection

The effect of riodoxol on herpes simplex type 1 viruses was studied. It was shown to affect multiplication and maturation of the virus as manifested in the appearance of virions with incomplete nucleoid structure and long-term presence of virions in cytoplasmic vacuoles in cells. Submicroscopic chan...

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Bibliographic Details
Published inVoprosy virusologiĭ no. 1; p. 90
Main Authors Stebaeva, L F, Nikolaeva, I S, Pershin, G N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1982
Subjects
Animals
Antiviral Agents - therapeutic use
Drug Evaluation, Preclinical
Eye - ultrastructure
Keratitis, Dendritic - drug therapy
Keratitis, Dendritic - microbiology
Microscopy, Electron
Morphogenesis - drug effects
Rabbits
Resorcinols - therapeutic use
Simplexvirus - drug effects
Simplexvirus - ultrastructure
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Summary:The effect of riodoxol on herpes simplex type 1 viruses was studied. It was shown to affect multiplication and maturation of the virus as manifested in the appearance of virions with incomplete nucleoid structure and long-term presence of virions in cytoplasmic vacuoles in cells. Submicroscopic changes suggest a dual effect of riodoxol on herpes simplex virus: on the DNA replicative cycle and on the stage of late maturation of virus at the time of its release from the nucleus.'
ISSN:0507-4088