Recent advances in enzymatic production of alpha-keto acids

Alpha-keto acid is a bifunctional organic compound containing both carboxyl and ketone groups, and widely applied in the industries of food, pharmaceutical and cosmetics. Based on the demand of eco-friendly process, safety and sustainable development, production of α-keto acids by enzymatic conversi...

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Published inShengwu gongcheng xuebao Vol. 35; no. 7; p. 1193
Main Authors Zhang, Quan, Song, Wei, Zhang, Can, Pei, Shanshan, Chen, Xiulai, Liu, Jia, Luo, Qiuling, Liu, Liming
Format Journal Article
LanguageChinese
Published China 25.07.2019
Subjects
enzymatic conversion
protein engineering
α-keto acids
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Summary:Alpha-keto acid is a bifunctional organic compound containing both carboxyl and ketone groups, and widely applied in the industries of food, pharmaceutical and cosmetics. Based on the demand of eco-friendly process, safety and sustainable development, production of α-keto acids by enzymatic conversion technology has been paid more and more attention. In this article, we review the status of α-keto acids biosynthesis from three aspects: enzymatic screening, enzymatic modification and optimization of enzymatic conversion conditions. Meanwhile, we also indicate future research directions for further improving α-keto acids production.
ISSN:1000-3061
DOI:10.13345/j.cjb.180455