Construction of controllable polyethylene glycol bioactive coating with hemocompatibility from the surface of modified glass substrate

A diblock copolymer, poly(ethylene glycol) methacrylate-block-glycidyl methacrylate (PEGMA-GMA), was prepared on glass substrate by surface-initiated atom transfer radical polymerization (SI-ATRP), and endothelial specific peptide Arg-Glu-Asp-Val (REDV) was immobilized at the end of the PEGMA-GMA po...

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Published inSheng wu yi xue gong cheng xue za zhi Vol. 36; no. 2; p. 260
Main Authors Wei, Yu, Zhang, Jingxun, Zhang, Yuzhong, Feng, Xiantao, Yang, Xuanhuang
Format Journal Article
LanguageChinese
Published China Sichuan Society for Biomedical Engineering 25.04.2019
Subjects
Atomic beam spectroscopy
Atomic force microscopy
Biocompatibility
Biocompatible Materials
Block copolymers
Blood
Brushes
Cell surface
Cells, Cultured
Coating
Coatings
Construction
Contact angle
Electrons
Endothelial Cells
Glass
Glass substrates
Humans
Immobilized Proteins
Methacrylates
Microscopy
Oligopeptides
Peptides
Photoelectron spectroscopy
Photoelectrons
Platelet Adhesiveness
Polyethylene glycol
Polyethylene Glycols
Polymer coatings
Polymerization
Polymers
Ring opening
Selectivity
Spectroscopy
Spectrum analysis
Substrates
Surface Properties
X ray photoelectron spectroscopy
poly(ethylene glycol) methacrylate
glycidyl methacrylate
surface-initiated atom transfer radical polymerization
active polymer coating
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Summary:A diblock copolymer, poly(ethylene glycol) methacrylate-block-glycidyl methacrylate (PEGMA-GMA), was prepared on glass substrate by surface-initiated atom transfer radical polymerization (SI-ATRP), and endothelial specific peptide Arg-Glu-Asp-Val (REDV) was immobilized at the end of the PEGMA-GMA polymer brush by ring opening reaction through the rich epoxy groups in the GMA. The structure and hydrophilicity of the polymer brushes were characterized by static water contact angle, X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM). The results showed that the REDV modified copolymer brushes were successfully constructed on the glass substrates. The REDV peptide immobilized onto surface was quantitatively characterized by ultraviolet-visible spectroscopy (UV-VIS). The blood compatibility of the coating was characterized by recalcification time and platelet adhesion assay. The results showed that the polymer coating had good blood compatibility. The multifunctional active polymer coating wi
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ISSN:1001-5515
DOI:10.7507/1001-5515.201705032