Hypothalamic alpha 2- and beta-adrenoceptor rhythms are correlated with circadian feeding: evidence from chronic methamphetamine treatment and withdrawal

The circadian regulation of food intake in rats is correlated with a bimodal rhythm of beta-adrenoceptor binding in the lateral hypothalamus and a unimodal rhythm of alpha 2-adrenoceptor binding in the medial hypothalamus. Chronic methamphetamine treatment provides evidence for a functional correlat...

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Bibliographic Details
Published inBrain research Vol. 321; no. 1; p. 83
Main Authors Kräuchi, K, Wirz-Justice, A, Morimasa, T, Willener, R, Feer, H
Format Journal Article
LanguageEnglish
Published Netherlands 29.10.1984
Subjects
Animals
Body Weight
Circadian Rhythm
Corticosterone - blood
Feeding Behavior - drug effects
Feeding Behavior - physiology
Hypothalamic Area, Lateral - physiology
Male
Methamphetamine - pharmacology
Rats
Rats, Inbred Strains
Receptors, Adrenergic, alpha - physiology
Receptors, Adrenergic, beta - physiology
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Summary:The circadian regulation of food intake in rats is correlated with a bimodal rhythm of beta-adrenoceptor binding in the lateral hypothalamus and a unimodal rhythm of alpha 2-adrenoceptor binding in the medial hypothalamus. Chronic methamphetamine treatment provides evidence for a functional correlation: beta-adrenoceptor binding in the lateral hypothalamus is reduced at dusk, together with reduction of food intake; alpha 2-adrenoceptor binding in the medial hypothalamus is increased at dawn, together with persistent food intake. Long-term changes in these two adrenergic systems are also correlated with homeostasis of food intake: 24-h mean beta-adrenoceptor binding is reduced and alpha 2-adrenoceptor binding is increased upon methamphetamine withdrawal, when rebound feeding occurs. Corticosterone, although normally coupled to adrenergic mechanisms that regulate feeding, is phase delayed after chronic methamphetamine treatment.
ISSN:0006-8993