Clinical Pharmacology of Antidiabetic Drugs

Clinical pharmacology is the study of the relationship between drugs and the body. It is not only necessary in the management of disease but is also important in the development of new therapies. Pharmacology can be divided into pharmacodynamics, the effect a drug has on the body, and pharmacokineti...

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Bibliographic Details
Published inDiabetes Drug Notes pp. 2 - 29
Main Authors Llano, Andrea, McKay, Gerry, Paterson, Ken
Format Book Chapter
LanguageEnglish
Published United Kingdom John Wiley & Sons, Incorporated 2022
John Wiley & Sons, Inc
Subjects
biosimilar insulin
cardiovascular outcome trials
Clinical pharmacology
clinical trials
drug development
pharmacodynamics
pharmacoeconomics
pharmacokinetics
pharmacovigilance
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Summary:Clinical pharmacology is the study of the relationship between drugs and the body. It is not only necessary in the management of disease but is also important in the development of new therapies. Pharmacology can be divided into pharmacodynamics, the effect a drug has on the body, and pharmacokinetics, the study of what the body does to the drug, and both will be considered with reference to glucose‐lowering therapies. Drug development and regulation in diabetes will also be considered. There have been considerable changes in the diabetes regulatory landscape recently, including cardiovascular outcome trials and the introduction of biosimilar insulin. Once medicines become available for use in the population, the process of pharmacovigilance to monitor safety is an important part of the post‐marketing process. Finally, pharmacoeconomics will be discussed, where economic analysis is used to determine the clinical benefits and cost‐effectiveness of new therapies.
ISBN:1119785006
9781119785002
DOI:10.1002/9781119785033.ch1