Progress in fungal polyketide biosynthesis

Fungal polyketides display complex structures and variously biological activities. Their biosynthetic pathways generally contain novel enzyme-catalyzed reactions. This review provides a summary of recent research advances in molecular mechanism of the biosynthesis of fungal polyketides including hig...

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Bibliographic Details
Published inShengwu gongcheng xuebao Vol. 34; no. 2; p. 151
Main Authors Chen, Xiwei, Xu, Meng, Feng, Cheng, Hu, Changhua
Format Journal Article
LanguageChinese
Published China 25.02.2018
Subjects
Fungal Proteins - metabolism
Fungi - enzymology
Industrial Microbiology
Multigene Family
Polyketide Synthases - metabolism
Polyketides - metabolism
Secondary Metabolism
natural products
gene cluster
enzymatic catalysis
fungal polyketide
biosynthesis
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Summary:Fungal polyketides display complex structures and variously biological activities. Their biosynthetic pathways generally contain novel enzyme-catalyzed reactions. This review provides a summary of recent research advances in molecular mechanism of the biosynthesis of fungal polyketides including highly-reducing polyketide synthases (HR-PKSs), non-reducing polyketide synthases (NR-PKSs), as well as polyketide-nonribosomal peptide synthase (PKS-NRPSs) and reducingnon- reducing polyketide synthase (HR-NR PKSs) hybrids. The elucidation of biosynthetic mechanism of many fungal polyketides provides guidance on the discovery of new biosynthetic gene cluster of fungal polyketide natural products and compounds with novel structures as well as their analogue.
ISSN:1000-3061
DOI:10.13345/j.cjb.170219