Comparative trial on the response of Plasmodium falciparum to halofantrine and mefloquine in Trat Province, eastern Thailand

With the appearance of strains of Plasmodium falciparum in the Trat Province, eastern Thailand, reported to have developed resistance to mefloquine there is a need for an alternative drug. This comparative trial with mefloquine and halofantrine has demonstrated extremely low cure rates with both dru...

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Bibliographic Details
Published inSoutheast Asian journal of tropical medicine and public health Vol. 23; no. 1; pp. 55 - 58
Main Authors KETRANGSEE, S, VIJAYKADGA, S, YAMOKGUL, P, JATAPADMA, S, THIMASARN, K, ROONEY, W
Format Journal Article
LanguageEnglish
Published Bangkok Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network 01.03.1992
Subjects
Administration, Oral
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials - administration & dosage
Antimalarials - adverse effects
Antimalarials - therapeutic use
Biological and medical sciences
Drug Resistance
Female
Humans
Malaria, Falciparum - drug therapy
Malaria, Falciparum - epidemiology
Malaria, Falciparum - parasitology
Male
Medical sciences
Mefloquine - administration & dosage
Mefloquine - adverse effects
Mefloquine - therapeutic use
Pharmacology. Drug treatments
Phenanthrenes - administration & dosage
Phenanthrenes - adverse effects
Phenanthrenes - therapeutic use
Thailand - epidemiology
Treatment Outcome
Thailand
Asia
Infection
Human
Protozoa
Plasmodium falciparum
Protozoal disease
Chemotherapy
Treatment
Malaria
Parasiticid
Sporozoa
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Summary:With the appearance of strains of Plasmodium falciparum in the Trat Province, eastern Thailand, reported to have developed resistance to mefloquine there is a need for an alternative drug. This comparative trial with mefloquine and halofantrine has demonstrated extremely low cure rates with both drugs (33.3% and 28.13% respectively), cross-resistance is suggested.
ISSN:0125-1562