A pharmacological dose of glucagon suppresses gastric emptying of a radiolabelled solid meal in humans

The effect of glucagon (143 nmol i.v. bolus followed by 430 nmol infused at a constant rate over 90 min) vs placebo (normal saline) on gastric emptying was examined in a blind randomized study in eight healthy males. The gastric emptying of a radiolabelled solid meal was measured with the use of a g...

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Bibliographic Details
Published inScandinavian journal of clinical and laboratory investigation Vol. 48; no. 8; p. 743
Main Authors Jonderko, G, Gołab, T, Jonderko, K
Format Journal Article
LanguageEnglish
Published England 01.12.1988
Subjects
Adult
Gastric Emptying - drug effects
Glucagon - administration & dosage
Humans
Male
Random Allocation
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Summary:The effect of glucagon (143 nmol i.v. bolus followed by 430 nmol infused at a constant rate over 90 min) vs placebo (normal saline) on gastric emptying was examined in a blind randomized study in eight healthy males. The gastric emptying of a radiolabelled solid meal was measured with the use of a gamma camera. Glucagon elicited a pronounced delay in gastric emptying in all subjects examined--mean gastric transit time MTT90 glucagon 44.2 +/- 0.22 min vs placebo 38.6 +/- 0.74 min, p less than 0.001.
ISSN:0036-5513