99mTc human immunoglobulin scintigraphy--a reliable method to detect joint activity in rheumatoid arthritis

The ability of 99mtechnetium labelled nonspecific, polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy to depict and quantify synovial inflammation was studied in 30 patients with rheumatoid arthritis (RA). All patients were injected with 350 MBq 99mTc-IgG and imaging was performed 4 h later....

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Bibliographic Details
Published inJournal of rheumatology Vol. 19; no. 9; p. 1371
Main Authors de Bois, M H, Arndt, J W, van der Velde, E A, van der Lubbe, P A, Westedt, M L, Pauwels, E K, Breedveld, F C
Format Journal Article
LanguageEnglish
Published Canada 01.09.1992
Subjects
Adult
Aged
Arthritis, Rheumatoid - diagnostic imaging
Arthritis, Rheumatoid - pathology
Arthritis, Rheumatoid - physiopathology
C-Reactive Protein - analysis
Female
Humans
Immunoglobulins
Joints - diagnostic imaging
Joints - pathology
Joints - physiopathology
Male
Middle Aged
Radionuclide Imaging
Synovial Membrane - diagnostic imaging
Synovial Membrane - pathology
Synovial Membrane - physiopathology
Synovitis - diagnosis
Synovitis - diagnostic imaging
Synovitis - pathology
Technetium
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Summary:The ability of 99mtechnetium labelled nonspecific, polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy to depict and quantify synovial inflammation was studied in 30 patients with rheumatoid arthritis (RA). All patients were injected with 350 MBq 99mTc-IgG and imaging was performed 4 h later. This resulted in excellent images of inflamed synovium. Scores for 99mTc-IgG joint scintigraphy correlated highly with scores for joint swelling and C-reactive protein levels, weakly with pain scores and not with radiographic scores of joint destruction. These results suggest that 99mTc-IgG joint scintigraphy may provide an objective test to detect synovitis and measure the activity of the disease.
ISSN:0315-162X