6-Allyl-5,6-dihydro-5-hydroxypyran-2-one, a lactone produced by a new Drechslera species: specified 1H and 13C NMR assignments, mutagenic and immunomodulating testings

A lactone (6-allyl-5,6-dihydro-5-hydroxypyran-2-one) was isolated from a new Drechslera sp. 1H and 13C NMR assignments, not previously specified, are published. No mutagenic activity on Ames/Salmonella test (strains TA98 and TA100 has been observed. Results on the respiratory metabolism of J774.1 mu...

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Bibliographic Details
Published inPharmazie Vol. 49; no. 8; p. 605
Main Authors Krivobok, S, Thomasson, F, Seigle-Murandi, F, Steiman, R, Bottex-Gauthier, C
Format Journal Article
LanguageEnglish
Published Germany 01.08.1994
Subjects
Adjuvants, Immunologic - isolation & purification
Adjuvants, Immunologic - pharmacology
Animals
Chromatography, High Pressure Liquid
Dogs
In Vitro Techniques
Macrophages - drug effects
Macrophages - immunology
Magnetic Resonance Spectroscopy
Mice
Mitosporic Fungi - chemistry
Mutagenicity Tests
Mutagens - isolation & purification
Mutagens - pharmacology
Pyrones - isolation & purification
Pyrones - pharmacology
Rats
Salmonella typhimurium - drug effects
Salmonella typhimurium - genetics
Tetrazolium Salts
Thiazoles
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Summary:A lactone (6-allyl-5,6-dihydro-5-hydroxypyran-2-one) was isolated from a new Drechslera sp. 1H and 13C NMR assignments, not previously specified, are published. No mutagenic activity on Ames/Salmonella test (strains TA98 and TA100 has been observed. Results on the respiratory metabolism of J774.1 murine macrophage indicate that the lactone might exhibit immunomodulating activity as a function of time of cellular contact and of concentration.
ISSN:0031-7144