Comparison of one-day oral dosing with three bismuth compounds for the suppression of Helicobacter pylori assessed by the 13C-urea breath test

Assessment of intragastric urease activity by the 13C-urea breath test was performed before and after one day of dosing with either De-Noltabs (tripotassium dicitrato bismuthate, one tablet 1 q.d.s.), Pepto-Bismol liquid (bismuth salicylate 30 ml q.d.s.), or Roter tablets (bismuth subnitrate, one ta...

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Published inAlimentary pharmacology & therapeutics Vol. 6; no. 1; pp. 97 - 102
Main Authors PREWETT, E. J, LUK, Y. W, FRASER, A. G, LAM, W. M, POUNDER, R. E
Format Journal Article
LanguageEnglish
Published Oxford Blackwell 01.02.1992
Subjects
Adult
Aged
Analysis of Variance
Biological and medical sciences
Bismuth - administration & dosage
Bismuth - pharmacology
Breath Tests
Carbon Dioxide - analysis
Digestive system
Female
Gastric Mucosa - drug effects
Gastric Mucosa - microbiology
Helicobacter pylori - drug effects
Helicobacter pylori - enzymology
Humans
Male
Medical sciences
Middle Aged
Organometallic Compounds - administration & dosage
Organometallic Compounds - pharmacology
Pharmacology. Drug treatments
Salicylates - administration & dosage
Salicylates - pharmacology
Urea
Urease - metabolism
Human
Urea
Breath test
Sensitivity resistance
Spirillales
Helicobacter pylori
Oral administration
Spirillaceae
Bacteria
Antiulcer agent
Pharmacokinetics
Bismuth Complexes
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Summary:Assessment of intragastric urease activity by the 13C-urea breath test was performed before and after one day of dosing with either De-Noltabs (tripotassium dicitrato bismuthate, one tablet 1 q.d.s.), Pepto-Bismol liquid (bismuth salicylate 30 ml q.d.s.), or Roter tablets (bismuth subnitrate, one tablet q.d.s.) in twelve Helicobacter pylori-positive patient volunteers. There was a significant decrease in the excess of 13CO2 after one day of dosing with each of the three bismuth compounds, but analysis of variance could detect no difference between the effects of the three compounds. Systemic absorption of bismuth following oral dosing with either Pepto-Bismol or Roter is minimal, yet both compounds have a suppressive effect on H. pylori similar to that of De-Noltab. This study suggests that the action of all three bismuth compounds is within the gastric lumen, and that systemic absorption of bismuth is not necessary for activity against H. pylori.
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ISSN:0269-2813
1365-2036