AB0711 VASCULAR CALCIFICATIONS IN LARGE VESSEL VASCULITIS

• Published in: Annals of the rheumatic diseases Vol. 82; no. Suppl 1; p. 1560
• Main Authors: Marvisi, C, Farì, R, Besutti, G, Spaggiari, L, Mancuso, P, Muratore, F, Galli, E, Pattacini, P, Salvarani, C
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.06.2023
• Subjects: Abdomen; Arteries; Arteriosclerosis; Arteritis; Atherosclerosis; Calcification; Calcification (ectopic); Cardiovascular diseases; Computed tomography; Diagnosis; Lymphoma; Medical imaging; Patients; Risk factors; Sex; Thorax; Vasculitis; Veins & arteries
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/annrheumdis-2023-eular.5876

BackgroundArterial wall calcifications are a hallmark of atherosclerosis and represent an important cardiovascular risk factor. Accelerated atherosclerosis and vascular calcifications have been reported in large vessel vasculitis (LVV), but data are scarce about the amount and localizations [1].ObjectivesThe aim of this study was to compare the prevalence, amount, and local distribution of arterial wall calcification evaluated on CT scan in LVVs versus lymphoma patients matched for age, sex, and year of diagnosis.MethodsAll consecutive patients diagnosed at our institution with LVVs from 2007 to 2018 with an available baseline PET-CT scan were included. Lymphoma patients were matched based on age, sex, and year of baseline PET-CT. CT images derived from baseline PET-CT scans of both patient groups were retrospectively reviewed by a single radiologist who, after setting a threshold of minimum 130 HU, semi-automatically computed vascular calcifications in three separate sites (coronaries, thoracic and abdominal arteries), quantified as Agatston, volume and mass scores. Calcifications in the two groups were compared for each site by using paired T-test. The effect of patient group was evaluated on the presence of calcifications in each site by means of adjusted conditional logistic regressions, and on the score of thoracic calcifications by means of adjusted regression.Results258 patients were enrolled, including Takayasu’s arteritis n=57, giant cell arteritis n=72 and lymphoma n=129. Thoracic artery calcifications were more represented in LVV patients, when compared with lymphoma patients (mean volume 2026 in LVVs vs 1014 in lymphomas, p=0.054). Coronary calcifications were higher in lymphoma patients (mean volume 104 in LVVs and 198 in lymphomas, p=0.13), whereas abdominal artery calcifications were equally distributed (mean volume 3220 in LVVs and 2712 in lymphomas). A diagnosis of LVV was associated with the presence of thoracic calcifications after adjusting by age and year of diagnosis (OR=4.13, 95%CI= 1.35-12.66; p=0.013), and with the volume score in the thoracic arteries (p=0.048).ConclusionWhen compared with lymphoma patients matched by age, sex, and year of diagnosis, LVV patients have higher calcification in the thoracic arteries, but not in coronary and abdominal arteries.References[1]Banerjee S. et al. Semin Arthritis Rheum 2020Acknowledgements:NIL.Disclosure of InterestsNone Declared.