The association between waist circumference and risk of mortality considering body mass index in 65- to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58000 elderly persons

Background For the elderly, the association between waist circumference (WC) and mortality considering body mass index (BMI) remains unclear, and thereby also the evidence base for using these anthropometric measures in clinical practice. This meta-analysis examined the association between WC catego...

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Bibliographic Details
Published inInternational journal of epidemiology Vol. 41; no. 3; pp. 805 - 817
Main Authors DE HOLLANDER, Ellen L, BEMELMANS, Wanda Je, BASSETT, Julie K, GILES, Graham G, ORSINI, Nicola, HEIM, Noor, VISSER, Marjolein, DE GROOT, Lisette Cpgm, BOSHUIZEN, Hendriek C, FRIEDRICH, Nele, WALLASCHOFSKI, Henri, GUALLAR-CASTILLON, Pilar, WALTER, Stefan, CAROLA ZILLIKENS, M, ROSENGREN, Annika, LISSNER, Lauren
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 2012
Subjects
abdominal obesity
adipose-tissue
all-cause mortality
Biological and medical sciences
cardiorespiratory fitness
cardiovascular-disease
coronary-heart-disease
Epidemiology
follow-up
General aspects
health outcomes
Medical sciences
middle-aged men
Miscellaneous
older-people
Public health. Hygiene
Public health. Hygiene-occupational medicine
Human
Mortality
Risk
Corporal biometry
Epidemiology
Metaanalysis
Body mass index
Waist circumference
Association
Cohort study
Risk factor
Elderly
Public health
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Summary:Background For the elderly, the association between waist circumference (WC) and mortality considering body mass index (BMI) remains unclear, and thereby also the evidence base for using these anthropometric measures in clinical practice. This meta-analysis examined the association between WC categories and (cause-specific) mortality within BMI categories. Furthermore, the association of continuous WC with lowest and increased mortality risks was examined. Methods Age-and smoking-adjusted relative risks (RRs) of mortality associated with WC-BMI categories and continuous WC (including WC and WC2) were calculated by the investigators and pooled by means of random-effects models. Results During a 5-year-follow-up of 32 678 men and 25 931 women, we ascertained 3318 and 1480 deaths, respectively. A large WC (men: >= 102 cm, women: >= 88 cm) was associated with increased all-cause mortality RRs for those in the 'healthy' weight {1.7 [95% confidence interval (CI): 1.2-2.2], 1.7 (95% CI: 1.3-2.3)}, overweight [1.1(95% CI: 1.0-1.3), 1.4 (95%: 1.1-1.7)] and obese [1.1 (95% CI: 1.0-1.3), 1.6 (95% CI: 1.3-1.9)] BMI category compared with the 'healthy' weight (20-24.9 kg/m(2)) and a small WC (
ISSN:0300-5771
1464-3685