An Enantioselective Synthesis of the ABD Tricycle for (-)-Phomactin A Featuring Rawal's Asymmetric Diels-Alder Cycloaddition

An enantioselective synthesis of the ABD-ring of (-)-phomactin A is described here. The sequence features Rawal's asymmetric Diels-Alder cycloaddition. The overall length is significantly reduced from our previous attempt.

Saved in:
Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 350; no. 18
Main Authors You, Ling-Feng, Hsung, Richard P, Bedermann, Aaron A, Kurdyumov, Aleksey V, Tang, Yu, Buchanan, Grant S, Cole, Kevin P
Format Journal Article
LanguageEnglish
Published Germany 01.12.2008
Subjects
Rawal’s 1-amino-3-siloxy-1,3-butadiene
phomactin A
intramolecular oxa-[3 + 3] annulation
Cr(III)-salen catalyst
asymmetric Diels-Alder cycloaddition
Online AccessGet full text

Cover

More Information
Summary:An enantioselective synthesis of the ABD-ring of (-)-phomactin A is described here. The sequence features Rawal's asymmetric Diels-Alder cycloaddition. The overall length is significantly reduced from our previous attempt.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200800552