More Than 12 % Polarization and 20 Minute Lifetime of 15N in a Choline Derivative Utilizing Parahydrogen and a Rhodium Nanocatalyst in Water

• Published in: Angewandte Chemie Vol. 130; no. 33; pp. 10852 - 10856
• Main Authors: McCormick, Jeffrey, Korchak, Sergey, Mamone, Salvatore, Ertas, Yavuz N., Liu, Zhiyu, Verlinsky, Luke, Wagner, Shawn, Glöggler, Stefan, Bouchard, Louis‐S.
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 13.08.2018
• Subjects: Biocompatibility; Catalysis; Catalysts; Chemistry; Choline; Contrast agents; Deuteration; Heterogene Katalyse; Hyperpolarisation; Hyperpolarization; In vivo methods and tests; Induced polarization; Magnetic resonance imaging; Parawasserstoff-induzierte Polarisation; Polarisationstransfer; Polarization; Quaternary ammonium salts; Relaxation time; Rhodium; Rhodium-Nanopartikel; Structure-function relationships
• ISSN: 0044-8249; 1521-3757
• DOI: 10.1002/ange.201804185

Hyperpolarization techniques are key to extending the capabilities of MRI for the investigation of structural, functional and metabolic processes in vivo. Recent heterogeneous catalyst development has produced high polarization in water using parahydrogen with biologically relevant contrast agents. A heterogeneous ligand‐stabilized Rh catalyst is introduced that is capable of achieving 15N polarization of 12.2±2.7 % by hydrogenation of neurine into a choline derivative. This is the highest 15N polarization of any parahydrogen method in water to date. Notably, this was performed using a deuterated quaternary amine with an exceptionally long spin‐lattice relaxation time (T1) of 21.0±0.4 min. These results open the door to the possibility of 15N in vivo imaging using nontoxic similar model systems because of the biocompatibility of the production media and the stability of the heterogeneous catalyst using parahydrogen‐induced polarization (PHIP) as the hyperpolarization method. Hohe Polarisation in Wasser: Bei Verwendung eines Nanopartikelkatalysators und einer effizienten Pulssequenz wird für ein Cholin‐Derivat in Wasser eine 15N‐Kernspinpolarisation oberhalb 12 % durch Parawasserstoff‐induzierte Polarisation (PHIP) erreicht. Die T1‐Relaxation ist mit über 20 min sehr lang, und durch die Vielseitigkeit in Bezug auf bekannte PHIP‐Methoden und Kerne (13C) ergeben sich neue Anwendungsmöglichkeiten in der Kernspintomographie.