Synthesis of 2-Oxo-1, 2-Dihydroquinoline Chemotype with Multiple Attachment Points as Novel Screening Compounds for Drug Discovery

The 2-oxo-1, 2-dihydroquinoline Chemotype is well represented among screening compound collection. However, the chemical space of 2-oxo-1, 2-dihydroquinoline has not been thoroughly investigated. In this work we report the synthesis of a small but novel 2-oxo-1, 2-dihydroquinoline compound array for...

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Bibliographic Details
Published inJSM Chemistry Vol. 4; no. 4
Main Authors Kurkin, Alexander V, Altieri, Andrea, Andreev, Ivan A, Debnath, Asim K
Format Journal Article
LanguageEnglish
Published United States 2016
Subjects
Drugs
Screening compounds
2-oxo-1, 2-dihydroquinoline
Synthesis
Natural products
Guanidine
Chemotype
Chemical scaffold
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Summary:The 2-oxo-1, 2-dihydroquinoline Chemotype is well represented among screening compound collection. However, the chemical space of 2-oxo-1, 2-dihydroquinoline has not been thoroughly investigated. In this work we report the synthesis of a small but novel 2-oxo-1, 2-dihydroquinoline compound array for screening purposes, especially in drug discovery, possessing three convenient point of diversity.
ISSN:2334-1831