Role of anticoagulation in lowering the mortality in hospitalized covid-19 patients

Objectives:To reducing the risk of venous thromboembolic (VTE) events and subsequent mortality in covid-19 patients is still a matter of research. This systematic review and meta-analysis serve the purpose of comparing the mortality associated with the intensity of anticoagulation in patients admitt...

Full description

Saved in:
Bibliographic Details
Published inSaudi medical journal Vol. 43; no. 6; pp. 541 - 550
Main Authors Aamir Waheed Muhammad, Rashid, Khalid, Tawfik, Rajab, Rajab, Ahmad, Adnan, Adnan H, Harris, Fayyaz, Ibad, Ahmad A, Basri Rabia, Khan, Yahya, Alhabib, Habib I, Elzouki Abdelnaser
Format Journal Article
LanguageEnglish
Published Riyadh Prince Sultan Military Medical City (PSMMC) 01.06.2022
Subjects
Anticoagulants
Clinical outcomes
COVID-19
Mortality
Severe acute respiratory syndrome coronavirus 2
Systematic review
Online AccessGet full text

Cover

More Information
Summary:Objectives:To reducing the risk of venous thromboembolic (VTE) events and subsequent mortality in covid-19 patients is still a matter of research. This systematic review and meta-analysis serve the purpose of comparing the mortality associated with the intensity of anticoagulation in patients admitted with covid-19.Methods:A total of 7120 patients were recruited in 11 studies comparing using prophylactic anticoagulants against therapeutic anticoagulants.Results:Our study showed that using prophylactic anticoagulants was associated with a 42% reduction in mortality compared to therapeutic anticoagulants (OR 0.58 (95% CI:0.676-0.499), p=0.000). Also, we assessed mortality in patients using no anticoagulants against using prophylactic anticoagulants. A total of 6069 patients were recruited in 4 studies in which 2 studies significantly favored prophylactic anticoagulants in terms of reducing mortality. Cumulatively, the meta-analysis showed that using prophylactic anticoagulants was associated with a 5% reduction in mortality but without any statistical significance: (OR 1.049 [95% CI 1.237 - 0.865]) (p=0.626).Conclusion:Our meta-analysis favors using prophylactic anticoagulation in covid-19 patients reduces all-cause mortality in comparison to therapeutic anticoagulation however the impact on mortality when compared with no anticoagulation was not significant.PROSPERO Number: CRD42021257320
ISSN:0379-5284
1658-3175
DOI:10.15537/smj.2022.43.6.20220046