Increased gastric juice leukotriene B4, C4 and E4 concentrations in children with Helicobacter pylori colonization

• Published in: Turkish journal of pediatrics Vol. 41; no. 3; pp. 335 - 339
• Main Authors: Kasirga, E, Coker, I, Aydogdu, S, Yağci, R V, Taneli, B, Gousseinov, A
• Format: Journal Article
• Language: English
• Published: Turkey Türk Pediatri Derneği 01.07.1999
• Subjects: Adolescent; Bacteria; Bacterial infections and mycoses; Bakteriler; Bakteriyel enfeksiyonlar ve mikozlar; Biopsy; Biyopsi; Child; Chromatography, Liquid; Female; Gastric Juice; Gastric Juice - chemistry; Gastric Mucosa; Gastric Mucosa - pathology; Gastrit; Gastritis; Helicobacter enfeksiyonları; Helicobacter Infections; Helicobacter Infections - microbiology; Helicobacter Infections - physiopathology; Helicobacter pylori; Humans; Kromatografi, sıvı; Leukotriene B4; Leukotriene B4 - analysis; Leukotriene C4; Leukotriene C4 - analysis; Leukotriene E4; Leukotriene E4 - analysis; Lipidler; Lipids; Lökotrien B4; Lökotrien C4; Lökotrien E4; Male; Mide mukozası; Mide sıvısı; Organic chemicals; Organik kimyasallar
• ISSN: 0041-4301

During recent years, the role of inflammatory lipid mediators in the pathophysiology of Helicobacter pylori (H. pylori) infections has been investigated in several studies. The concentrations of leukotrienes (LTs) in gastric juice from H. pylori positive (n = 13) and negative (n = 18) children with recurrent abdominal pain were studies in order to determine whether these lipid inflammatory mediators are involved in local and systemic biological actions. Gastric juice samples and biopsy specimens of mucosa were obtained endoscopically from 31 patients with recurrent abdominal pain for assessment of LTs and histopathological examination. In this study, all children with recurrent abdominal pain were investigated by rapid urease test and histological assessment for H. pylori colonization. Leukotriene levels were measured by high performance liquid chromatography (HPLC) and radioimmunoassay (RIA) in gastric juice samples. Gastric juice LTB4, LTC4, and LT4 levels were significantly higher in patients with H. pylori colonization than in children without H. pylori colonization. These results indicate that increased gastric content of proinflammatory mediators (LTB4, LTC4, and LT4) may be related to the pathogenesis of H. pylori-associated gastritis.