ACE2 and coronavirus - a question of balance and dynamics?

The new SARS-CoV-2 virus enters cells via angiotensin-converting enzyme 2 (ACE2). ACE2 counteracts ACE and angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and has critical functions in the lung and cardiovascular system. SARS-CoV was found to down-regulate ACE2, leaving angiotensin...

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Bibliographic Details
Published inLäkartidningen Vol. 117
Main Authors Lundström, Annika, Sandén, Per
Format Journal Article
LanguageSwedish
Published Sweden 17.04.2020
Subjects
Angiotensin II - physiology
Angiotensin-Converting Enzyme 2
Betacoronavirus - pathogenicity
Coronavirus
Coronavirus Infections - virology
COVID-19
Humans
Pandemics
Peptidyl-Dipeptidase A - physiology
Pneumonia, Viral - virology
Renin-Angiotensin System - physiology
Risk Factors
SARS-CoV-2
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Summary:The new SARS-CoV-2 virus enters cells via angiotensin-converting enzyme 2 (ACE2). ACE2 counteracts ACE and angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and has critical functions in the lung and cardiovascular system. SARS-CoV was found to down-regulate ACE2, leaving angiotensin II unbalanced in affected organs.  A similar effect of SARS-CoV-2 could partly explain risk factors and symptoms, and could potentially be treatable.
ISSN:1652-7518