Impact of genetic variation in the vasopressin 1a receptor on the development of organ failure in patients admitted for acute decompensation of liver cirrhosis

• Published in: European journal of gastroenterology & hepatology
• Main Authors: Kerbert, Annarein J C, Schaapman, Jelte J, van der Reijden, Johan J, Amorós Navarro, Àlex, McCormick, Aiden, van Hoek, Bart, Arroyo, Vicente, Ginès, Pere, Jalan, Rajiv, Vargas, Victor, Stauber, Rudolf, Verspaget, Hein W, Coenraad, Minneke J
• Format: Journal Article
• Language: English
• Published: England 10.01.2017
• ISSN: 1473-5687
• DOI: 10.1097/MEG.0000000000000834

Vasopressin receptor-mediated vasoconstriction is considered to be involved in the pathogenesis of organ failure in acute-on-chronic liver failure (ACLF). We studied the association between six single nucleotide polymorphisms (SNPs) of the vasopressin 1a receptor gene and the development of organ failure in 826 patients admitted for acute decompensation of liver cirrhosis (n=641) or ACLF (n=185). No associations were found for SNPs with the presence of circulatory or renal failure. A C>T mutation in SNP rs7308855 and a T>A mutation in SNP rs7298346 showed an association with the presence of coagulation failure in the entire population (n=61, P=0.024 and 0.060, respectively) and in the subgroup of patients with ACLF (n=44, P=0.081 and 0.056, respectively). Genetic variation in the vasopressin 1a receptor was found not to be associated with circulatory or renal failure, but with the presence of coagulation failure in patients with acute decompensation of liver cirrhosis and ACLF.