Propylene glycol inactivates respiratory viruses and prevents airborne transmission

Viruses are vulnerable as they transmit between hosts and we aimed to exploit this critical window. We found that the ubiquitous, safe, inexpensive and biodegradable small molecule propylene glycol (PG) has robust virucidal activity. Propylene glycol rapidly inactivates influenza, SARS-CoV-2 and a b...

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Bibliographic Details
Published inbioRxiv
Main Authors Styles, Christine T, Zhou, Jie, Flight, Katie E, Brown, Jonathan C, Michael Vanden Oever, Peacock, Thomas P, Wang, Ziyin, Millns, Rosie, O'neill, John S, Barclay, Wendy S, Tregoning, John S, Edgar, Rachel S
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 14.02.2023
Subjects
Infectivity
Influenza
Propylene glycol
Public health
Severe acute respiratory syndrome coronavirus 2
Viruses
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Summary:Viruses are vulnerable as they transmit between hosts and we aimed to exploit this critical window. We found that the ubiquitous, safe, inexpensive and biodegradable small molecule propylene glycol (PG) has robust virucidal activity. Propylene glycol rapidly inactivates influenza, SARS-CoV-2 and a broad range of other enveloped viruses, and reduces disease burden in mice when administered intranasally at concentrations commonly found in nasal sprays. Most critically, aerosolized PG efficiently abolishes influenza and SARS-CoV-2 infectivity within airborne droplets, potently preventing infection at levels significantly below those well-tolerated by mammals. We present PG vapor as a first-in-class non-toxic airborne virucide, to prevent transmission of existing and emergent viral pathogens, with clear and immediate implications for public health.Competing Interest StatementThe authors have declared no competing interest.
DOI:10.1101/2023.02.13.528349