The defects of the hippocampal ripples and theta rhythm in depression, and the effects of physical exercise on their amelioration

The pathophysiology of depression remains elusive, and its early diagnostic method has not been established. Accumulated evidence demonstrate that environmental stress affects the hippocampus, functioning in cognition and sociality, and causes various depressive symptoms. In addition, recent finding...

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Bibliographic Details
Published inbioRxiv
Main Authors Koketsu, Shinnosuke, Matsubara, Kohki, Ueki, Yoshino, Shinohara, Yoshiaki, Inoue, Koichi, Murakami, Satona, Ueki, Takatoshi
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 02.02.2023
Subjects
Cognition
Environmental stress
Hippocampus
Inflammation
Theta rhythms
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Summary:The pathophysiology of depression remains elusive, and its early diagnostic method has not been established. Accumulated evidence demonstrate that environmental stress affects the hippocampus, functioning in cognition and sociality, and causes various depressive symptoms. In addition, recent findings showed that environmental stress influenced the hippocampal activity correlated with neuroinflammation, and impaired the hippocampal sharp wave ripples (SWRs), pattens of spike sequences, and the theta rhythms, a strong oscillation observed in the hippocampus.Competing Interest StatementThe authors have declared no competing interest.
DOI:10.1101/2023.01.30.526359