Drosophila centrocortin is dispensable for centriole duplication but contributes to centrosome separation

Centrosomes are microtubule-organizing centers that duplicate exactly once to organize the bipolar mitotic spindle required for error-free mitosis. Prior work indicated that Drosophila centrocortin ( cen ) is required for normal centrosome separation, although a role in centriole duplication was not...

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Bibliographic Details
Published inbioRxiv
Main Authors Mehta, Dipen S, Ryder, Pearl V, Lee, Jina, Zein-Sabatto, Hala, Lerit, Dorothy A
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 01.09.2021
Subjects
Centrosomes
Drosophila
Embryos
Insects
Mitosis
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Summary:Centrosomes are microtubule-organizing centers that duplicate exactly once to organize the bipolar mitotic spindle required for error-free mitosis. Prior work indicated that Drosophila centrocortin ( cen ) is required for normal centrosome separation, although a role in centriole duplication was not closely examined. Through time-lapse recordings of rapid syncytial divisions, we monitored centriole duplication and the kinetics of centrosome separation in control versus cen null embryos. Our data suggest that although cen is dispensable for centriole duplication, it contributes to centrosome separation. Competing Interest Statement The authors have declared no competing interest.
DOI:10.1101/2021.08.31.458397