Degradable endovascular neural interface for minimally invasive neural recording and stimulation

Neural recording and stimulation have been widely used to mitigate traumatic injuries, neurodegenerative diseases or mental disorders. Most neural interfaces commonly require invasive surgery, potentially entailing both transient and permanent complications. A promising strategy designed to overcome...

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Bibliographic Details
Published inbioRxiv
Main Authors Fanelli, Adele, Ferlauto, Laura, Zollinger, Elodie Genevieve, Brina, Olivier, Reymond, Philippe, Machi, Paolo, Ghezzi, Diego
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 25.03.2021
Subjects
Brain injury
Cardiovascular system
Cerebrovascular system
Computer applications
Implants
Inflammation
Interfaces
Mental disorders
Neurodegenerative diseases
Neurological diseases
Surgery
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Summary:Neural recording and stimulation have been widely used to mitigate traumatic injuries, neurodegenerative diseases or mental disorders. Most neural interfaces commonly require invasive surgery, potentially entailing both transient and permanent complications. A promising strategy designed to overcome these risks involves exploiting the cerebrovascular system as an access route to the neural tissue. Here we present a novel endovascular neural interface for neural recording and stimulation, fully polymeric and degradable. This concept might allow for better integration of the device in the body, reduced inflammatory reaction, the possibility of replacing the implant after degradation, and avoiding removal surgeries. The vasculature's strategic distribution and the use of soft polymers for the device's fabrication will permit targeting both the brain vasculature and the peripheral system. Therefore, this novel endovascular neural interface will broaden the range of applications from neurological diseases and mental disorders to bioelectronics medicine. Competing Interest Statement The authors have declared no competing interest.
DOI:10.1101/2021.03.24.436737