Phase-based cortical synchrony is affected by prematurity

Abstract Inter-areal synchronization by phase-phase correlations (PPC) of cortical oscillations mediates many higher neurocognitive functions, which are often affected by prematurity, a globally prominent neurodevelopmental risk factor. Here, we used electroencephalography (EEG) to examine brain-wid...

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Bibliographic Details
Published inbioRxiv
Main Authors Yrjölä, Pauliina, Stjerna, Susanna, J Matias Palva, Vanhatalo, Sampsa, Tokariev, Anton
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 18.02.2021
Subjects
Cognition
EEG
Infants
Neonates
Oscillations
Risk factors
Sleep
Synchronization
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Summary:Abstract Inter-areal synchronization by phase-phase correlations (PPC) of cortical oscillations mediates many higher neurocognitive functions, which are often affected by prematurity, a globally prominent neurodevelopmental risk factor. Here, we used electroencephalography (EEG) to examine brain-wide cortical PPC networks at term-equivalent age, comparing human infants after early prematurity to a cohort of healthy controls. We found that prematurity affected these networks in a sleep state-specific manner, and the differences between groups were also frequency-selective, involving brain-wide connections. The strength of synchronization in these networks was predictive of clinical outcomes in the preterm infants. These findings show that prematurity affects PPC networks in a clinically significant manner suggesting early functional biomarkers of later neurodevelopmental compromise to be used in clinical and translational studies after early neonatal adversity. Competing Interest Statement The authors have declared no competing interest. Footnotes * ↵* These authors contributed equally * Competing interests, The author declares that no competing interests exist.
DOI:10.1101/2021.02.15.431226