Dysregulated gene expression of imprinted and X-linked genes: a link to poor development of bovine haploid androgenetic embryos

• Published in: bioRxiv
• Main Authors: Aguila, Luis, Therrien, Jacinthe, Suzuki, Joao, García, Mónica, Trindade, Amanda, Smith, Lawrence C
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 24.10.2020
• Subjects: Developmental stages; Embryogenesis; Enucleation; Epigenetics; Gene expression; Genomes; Genomic imprinting; Haploidy; KCNQ1 protein; KCNQ1OT1 protein; Methyltransferase; Non-coding RNA; Potassium channels (voltage-gated); X-chromosome inactivation

Abstract Mammalian uniparental embryos are efficient models for genome imprinting research and allow studies on the contribution of the paternal and maternal genome to early embryonic development. In this study, we analyzed different methodologies for production of bovine haploid androgenetic embryo...