Biomolecular recognition of the glycan neoantigen CA19-9 by distinct antibodies

• Published in: bioRxiv
• Main Authors: Borenstein-Katz, Aliza, Warszawski, Shira, Amon, Ron, Nova Tasnima, Yu, Hai, Chen, Xi, Padler-Karavani, Vered, Sarel Jacob Fleishman, Diskin, Ron
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 17.02.2021
• Subjects: Affinity; Antibodies; Antigens; Cell surface; Computer applications; Crystallography; Glycolipids; Glycoproteins; Neoantigens; Patent applications; Polysaccharides; X-ray crystallography

ABSTRACT Glycans decorate cell surface, secreted glycoproteins and glycolipids. Altered glycans are often found in cancers. Despite their high diagnostic and therapeutic potentials, glycans are polar and flexible molecules that are quite challenging for the development and design of high-affinity bi...