Molecular Transport of the Zika Virus by the Human Cytoplasmic Dynein-1

Zika virus (ZIKV) infection is a major public health threat, making the study of its biology a matter of great importance. By analyzing the viral-host protein interactions and proposing them as new drug targets, we would diminish the emergence of new resistant strains. In this work, we have shown th...

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Bibliographic Details
Published inbioRxiv
Main Authors Dan Israel Zavala-Vargas, Carbajal, Giovani Visoso, Cedillo-Barron, Leticia, Filisola-Villasenor, Jessica Georgina, Romel Rosales Ramirez, Ludert, Juan E, Morales-Rios, Edgar
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 16.06.2022
Subjects
Dimerization
Dynactin
Dynein
Env protein
Protein interaction
Public health
Replication
Therapeutic targets
Vero cells
Viral envelope proteins
Zika virus
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Summary:Zika virus (ZIKV) infection is a major public health threat, making the study of its biology a matter of great importance. By analyzing the viral-host protein interactions and proposing them as new drug targets, we would diminish the emergence of new resistant strains. In this work, we have shown that human cytoplasmic dynein-1 (Dyn) interacts with the ZIKV. We additionally demonstrate that the envelope protein of the ZIKV and the dimerization domain of the heavy chain of Dyn binds directly without dynactin or cargo adaptor. In addition, we have analyzed this interaction in Vero cells, where we are proposing that the interaction ZIKV-Dyn is finely tuned within the replication cycle. Altogether, our data suggest a new step in the previously described replication cycle of the ZIKV, introducing a suitable molecular target to modulate infection by ZIKV. Competing Interest Statement The authors have declared no competing interest.
DOI:10.1101/2022.06.15.496315