Degeneracy in the neurological model of auditory speech repetition

• Published in: bioRxiv
• Main Authors: Noor Sajid, Andrea Gajardo Vidal, Ekert, Justyna O, Lorca, Diego, Team, Ploras, Hope, Thomas M, Green, David W, Friston, Karl J, Price, Cathy J
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 27.03.2022
• Subjects: Brain injury; Brain mapping; Broca's area; Cortex (auditory); Cortex (motor); Frontal lobe; Functional magnetic resonance imaging; Hearing; Hemispheric laterality; Information processing; Neural networks; Repetition; Speech; Wernicke's area
• DOI: 10.1101/2022.03.25.485823

In the neurological model of language, repeating heard speech involves four left hemisphere regions: primary auditory cortex for processing sounds; Wernicke's area for processing auditory images of speech; Broca's area for processing motor images of speech; and primary motor cortex for overt speech articulation. Previous functional-MRI (fMRI) studies confirm that auditory repetition activates these regions. Here, we used dynamic causal modelling (DCM) to test how the four regions interact with each other during single word and pseudoword auditory repetition. Contrary to expectation, we found that, for both word and pseudoword repetition, the effective connectivity between Wernicke's and Broca's areas was predominantly bidirectional and inhibitory; activity in the motor cortex could be driven by either Wernicke's area or Broca's area; and the latter effect varied both within and between individuals. Such variability speaks to degenerate functional architectures that support auditory repetition and may explain resilience to functional loss after brain damage. Competing Interest Statement The authors have declared no competing interest.