Freshly Thawed Cryobanked Human Neural Stem Cells Engraft within Endogenous Neurogenic Niches and Restore Cognitive Function Following Chronic Traumatic Brain Injury

• Published in: bioRxiv
• Main Authors: Badner, Anna, Reinhardt, Emily K, Nguyen, Theodore V, Midani, Nicole, Marshall, Andrew T, Lepe, Cherie, Echeverria, Karla, Lepe, Javier, Torrecampo, Vincent, Bertan, Sara H, Tran, Serinee H, Anderson, Aileen J, Cummings, Brian J
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 24.07.2020
• Subjects: Brain stem; Cell culture; Cell therapy; Chemotactic response; Cognitive ability; CXCL12 protein; CXCR4 protein; Dentate gyrus; Doublecortin protein; Immunodeficiency; Inflammation; Meninges; Navigation behavior; Neural stem cells; Recovery of function; Spatial discrimination learning; Spatial memory; Stem cell transplantation; Stem cells; Thawing; Transplants & implants; Traumatic brain injury; Ventricle (lateral)

Human neural stem cells (hNSCs) have potential as a cell therapy following traumatic brain injury (TBI). While various studies have demonstrated the efficacy of NSCs from on-going culture, there is a significant gap in our understanding of freshly thawed cells from cryobanked stocks - a more clinica...