The Progression of Intracerebral Hemorrhage (ICH) is Related to the Expression of Integrin Β1 (ITGB1)

Background: Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the...

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Bibliographic Details
Published inChinese Neurosurgical Journal
Main Authors Hai-Yang, Ma, Xu, Yan, Chun-You, Qiao, Peng, Yi, Ding, Qi, Li-Zhong, Wang, Jun-Fei, Yan, Hou, Yuan, Di, Fei
Format Web Resource
LanguageEnglish
Published Durham Research Square 18.01.2021
Subjects
Hemorrhage
Quality of life
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Summary:Background: Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels. This study explored the relationship between expression of ITGB1, ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance. Methods: The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively. Results: Furthermore, the results demonstrated that ITGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues. Conclusions: In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.
DOI:10.21203/rs.3.rs-45466/v3