The somato-cognitive action network links diverse neuromodulatory targets for Parkinson's disease

The newly-recognized somato-cognitive action network (SCAN) is posited to be important in movement coordination. Functional disruptions in Parkinson's disease (PD) correspond with complex, non-effector-specific motor symptoms, indicating that SCAN dysfunction may underlie these symptoms. Along...

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Bibliographic Details
Published inbioRxiv
Main Authors Ren, Jianxun, Zhang, Wei, Dahmani, Louisa, Hu, Qingyu, Jiang, Changqing, Bai, Yan, Gong-Jun, Ji, Zhou, Ying, Zhang, Ping, Wang, Weiwei, Wang, Kai, Wang, Meiyun, Li, Luming, Wang, Danhong, Liu, Hesheng
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 14.12.2023
Subjects
Cognitive ability
Movement disorders
Neural networks
Neurodegenerative diseases
Neuromodulation
Parkinson's disease
Patent applications
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Summary:The newly-recognized somato-cognitive action network (SCAN) is posited to be important in movement coordination. Functional disruptions in Parkinson's disease (PD) correspond with complex, non-effector-specific motor symptoms, indicating that SCAN dysfunction may underlie these symptoms. Along the same lines, the SCAN may link multiple neuromodulatory targets used for PD treatment. To investigate the role of the SCAN in PD, we leveraged resting-state precision functional mapping, analyzing data from 673 individuals across 6 independent datasets and 5 types of neuromodulation. Our findings revealed functional abnormalities within the SCAN in PD patients and the selective involvement of the SCAN in diverse neuromodulatory targets. Moreover, our data suggests causal links between SCAN connectivity changes and motor symptom alleviation following both invasive and non-invasive neuromodulation. Collectively, these findings underscore the critical role of the SCAN in the pathophysiology of PD and its brain stimulation treatments, and suggest the SCAN as a promising candidate target for neuromodulation.Competing Interest StatementH.L. is the chief scientist of Neural Galaxy Inc. Luming Li serve on the scientific advisory board for Beijing Pins Medical Co., Ltd and are listed as inventors in issued patents and patent applications on the deep brain stimulator used in this work. Other authors declare no conflict of interest regarding the publication of this work.
DOI:10.1101/2023.12.12.571023