77 Sex cord stromal and germ cell ovarian cancer – is there a racial disparity?

• Published in: International journal of gynecological cancer Vol. 30; no. Suppl 3; p. A42
• Main Authors: Liao, C, Guerra, R, Reyes, F, Argueta, C, Mann, A, Abel, M, Kapp, D, Chan, J
• Format: Journal Article
• Language: English
• Published: Oxford BMJ Publishing Group LTD 01.11.2020
• Subjects: Asian people; Histology; Ovarian cancer; Tumors
• ISSN: 1048-891X; 1525-1438
• DOI: 10.1136/ijgc-2020-IGCS.73

ObjectivesTo determine the incidence and presentation of sex cord stromal and germ cell ovarian cancers in various racial groups.MethodsData was obtained from the United States Cancer Statistics (USCS) and National Cancer Database (NCDB) national databases from 2004–2016. Chi squared was used for statistical analysis.ResultsOf 8,917 women, 48.2% were diagnosed with sex cord stromal and 52.5% with germ cell ovarian cancer. Between 2004 and 2016, the age-adjusted incidence of sex cord stromal was 0.50 (per 100,000) in Blacks compared to 0.23 in Whites and 0.14 in Asians. The incidence for germ cell tumors was 0.40 (per 100,000) in Whites, 0.46 in Blacks, and 0.44 in Asians. Based on the NCDB data, the proportion of sex cord stromal tumor was 5.6% in Blacks compared to 1.5% Whites and 1.6% in Asians. Of the sex cord stromal tumors, the most common histology was granulosa cell at 85%, 84%, and 77.5% for Black, White, and Asian participants, respectively. The proportion of germ cell tumors in Blacks was 4.4% vs. 2.0% in Whites and 3.9% in Asians. Of germ cell tumors, the most common histology was dysgerminoma for Whites at 22.3%, immature teratoma in Blacks at 28.0%, and immature teratoma at 26.9% for Asians.ConclusionsOur data suggest that Black women are more likely to be diagnosed with sex cord stromal tumors compared to White and Asian women. Black and Asian women also had more germ cell cancer than White women.