Adaptation of a quantitative trait to a changing environment: new analytical insights on the asexual and infinitesimal sexual models

• Published in: bioRxiv
• Main Authors: Garnier, Jimmy, Cotto, Olivier, Bourgeron, Thibault, Bouin, Emeric, Lepoutre, Thomas, Ronce, Ophelie, Calvez, Vincent
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 31.01.2023
• Subjects: Biodiversity; Environmental changes; Evolution; Heredity; Mutation; Phenotypes; Phenotypic variations; Population; Reproductive fitness
• DOI: 10.1101/2022.06.22.497192

Predicting the adaptation of populations to a changing environment is crucial to assess the impact of human activities on biodiversity. Many theoretical studies have tackled this issue by modeling the evolution of quantitative traits subject to stabilizing selection around an optimum phenotype, whose value is shifted continuously through time. In this context, the population fate results from the equilibrium distribution of the trait, relative to the moving optimum. Such a distribution may vary with the shape of selection, the system of reproduction, the number of loci, the mutation kernel or their interactions. Here, we develop a methodology that provides quantitative measures of population maladaptation and potential of survival directly from the entire profile of the phenotypic distribution, without any a priori on its shape. We investigate two different models of reproduction (asexual and infinitesimal sexual models of inheritance), with general forms of selection. In particular, we recover that fitness functions such that selection weakens away from the optimum lead to evolutionary tipping points, with an abrupt collapse of the population when the speed of environmental change is too high. Our unified framework furthermore allows highlighting the underlying mechanisms that lead to this phenomenon. More generally, it allows discussing similarities and discrepancies between the two reproduction models, the latter being ultimately explained by different constraints on the evolution of the phenotypic variance. We demonstrate that the mean fitness in the population crucially depends on the shape of the selection function in the sexual infinitesimal model, in contrast with the asexual model. In the asexual model, we also investigate the effect of the mutation kernel and we show that kernels with higher kurtosis tend to reduce maladaptation and improve fitness, especially in fast changing environments.Competing Interest StatementThe authors have declared no competing interest.Footnotes* In this new version, we clarified the derivation of our model and the asymptotics we used. We also included stochastic simulations to compare with our deterministic approximations. Finnaly, we enhanced our analysis on the tipping points, which occurs in our model.