A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes

Abstract Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions. Calculations suggest that the nanoscale geometric changes and mechanic...

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Bibliographic Details
Published inbioRxiv
Main Author Kim, Jichul
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 17.12.2020
Subjects
Adhesion
Cell adhesion
Cell membranes
Lipid membranes
Lipids
Mechanotransduction
Signal transduction
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Summary:Abstract Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions. Calculations suggest that the nanoscale geometric changes and mechanical pulling applied on lipid membranes affect the generation of cellular traction forces and signaling transduction at focal adhesions. This work provides predictions on how lipid membranes contribute to mechanotransduction at cellular focal adhesions. Significance statement Focal adhesion machinery formed across cell membranes orchestrates a variety of signaling and adhesive molecules to function for important cellular physiologies. Although there are evidences that lipid membranes are involved in mechanical transduction at focal adhesions, how the detailed mechanical response of membranes contributes to the process is not identified yet. With numerous data previously identified, predictions made by theoretical modeling suggest that the nonlinear pulling response of lipid membranes serves as a key factor to interpret mechanotransduction at focal adhesions. Competing Interest Statement The authors have declared no competing interest.
DOI:10.1101/2020.12.16.423152