Dual STDP processes at Purkinje cells contribute to distinct improvements in accuracy and vigor of saccadic eye movements

• Published in: bioRxiv
• Main Authors: Fruzzetti, Lorenzo, Kalidindi, Hari Teja, Antonietti, Alberto, Cristiano Alessandro, Geminiani, Alice, Casellato, Caludia, Falotico, Egidio, D'angelo, Egidio Ugo
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 16.03.2022
• Subjects: Accuracy; Cerebellum; Embedding; Eye movements; Firing pattern; Kinematics; Long-term depression; Long-term potentiation; Motor task performance; Neural networks; Purkinje cells; Saccadic eye movements; Vigor
• DOI: 10.1101/2022.03.14.483471

Saccadic eye-movements play a crucial role in visuo-motor control by allowing rapid foveation onto new targets. However, the neural processes governing saccades adaptation are not fully understood. Saccades, due to the short-time of execution (20-100 ms) and the absence of sensory information for online feedback control, must be controlled in a ballistic manner. Incomplete measurements of the movement trajectory, such as the visual end-point error, are supposedly used to form internal predictions about the movement kinematics resulting in predictive control. In order to characterize the synaptic and neural circuit mechanisms underlying predictive saccadic control, we have reconstructed the saccadic system in a digital controller embedding a spiking neural network of the cerebellum with spike timing-dependent plasticity (STDP) rules driving parallel fiber - Purkinje cell long-term potentiation and depression (LTP and LTD). This model implements a control policy based on a dual plasticity mechanism, resulting in the identification of the roles of LTP and LTD in optimizing saccade movement control: it turns out that LTD regulates the accuracy and LTP the speed (vigor) of the ballistic eye movement. The control policy also required cerebellar PCs to be divided into two subpopulations, characterized by burst or pause responses. To our knowledge, this is the first model that explains in mechanistic terms the accuracy and vigor regulation of ballistic eye movements in forward mode exploiting spike-timing to regulate firing in different populations of the neuronal network. This elementary model of saccades could be extended and applied to other more complex cases in which single jerks are concatenated to compose articulated and coordinated movements. Competing Interest Statement The authors have declared no competing interest.